What is 5-HTP?

5-HTP stands for 5-hydroxytryptophan. It is a substance that is formed in the body from the essential amino acid L-tryptophan. In supplements, 5-HTP is often presented as Griffonia extract (from the seed of Griffonia simplicifolia), or as part of a 5-HTP complex with other micronutrients.

Origin: 5-HTP from Griffonia simplicifolia

Many products mention “5-HTP Griffonia” because the raw material is usually extracted from the seeds of Griffonia simplicifolia. On the label you often see terms such as strong>Griffonia extract,standardized extract or a percentage of 5-HTP. That percentage says something about the concentration of 5-HTP in the extract raw material used.

What forms does 5-HTP come in?

• 5-HTP capsules – practical, often with a fixed amount per capsule.
• 5-HTP tablets – similar to capsules, depending on excipients and composition.
• 5-HTP powder – less common; requires accuracy in weighing and use.
• 5-HTP complex – combinations with, for example, magnesium or vitamin B6 (composition varies per brand).

Which form is “best” usually depends on your preference (convenience, dosage per portion and composition).

What should you pay attention to when choosing a 5-HTP supplement?

• Transparent label: it clearly states “5-HTP” and (if applicable) the origin Griffonia simplicifolia?
• standardized extract: sometimes a percentage is mentioned; this gives an indication of the 5-HTP concentration in the extract.
• Purity & quality: look at brand reliability, production standards and any quality controls that the brand communicates.
• Excipients: check whether there are any unnecessary additives, especially if you are sensitive to certain fillers.
• Combinations: for a 5-HTP complex, the formula differs per product; so compare ingredients and quantities.