Do you want to slow down aging and optimize your energy levels? Then you have probably already come across NMN (Nicotinamide Mononucleotide) – a powerful NAD⁺ booster that is attracting the attention of scientists, doctors and biohackers worldwide.
Everyone the Buy NMN powder from Skins Unlimited is very enthusiastic, which is enough proof for us as experts in longevity supplements.
But what do international doctors and scientists say about NMN? In this article we list the opinions and statements of leading professionals for you. Factual, transparent and inspiring.
Dr. David Sinclair – Harvard pioneer in longevity
Background: Genetic researcher at Harvard Medical School, known worldwide for his bestseller Lifespan: Why We Age and Why We Don't Have To.
“NMN increases my NAD⁺ levels and activates sirtuins. I take 1 gram daily.” — Lifespan, podcasts & In terviews
[1]
Sinclair uses 1 gram of NMN daily, combined with resveratrol and metformin or berberine. His goal? Cell repair, sirtuin activation and delaying biological aging.
Dr. Andrew Huberman – Neuroscience with nuance
Background: Neurobiologist and professor at Stanford University, known for the popular Huberman Lab Podcast.
“NMN can increase NAD⁺ and optimize energy… but human evidence is still limited.” — Huberman Lab Podcast AMA #12
[2]
Huberman may take 1–2 g sublingually (under the tongue) of NMN himself and discuss the benefits for mitochondrial energy and cognitive performance in his podcast. At the same time, he emphasizes the importance of more human research.
Dr. Rhonda Patrick – Science with Integrity
Background: PhD in biomedical sciences, founder of FoundMyFitness, known for its accessible explanations of scientific research.“NMN and NR seem to do remarkable things to rodents.” — FoundMyFitness Podcast[3]Patrick is enthusiastic about preclinical research and the effect of NMN in animal models. It remains cautiously positive for humans, as long as long-term studies are still lacking.
Dr. Peter Attia – Critical but curious
Background: Doctor specialized in longevity and preventive medicine, known for the podcast The Drive and his book OutLive.
“TakIn g oral NAD⁺ precursors like NMN and NR is the most effective method for replenishIn g NAD⁺ levels.”
— NAD.com article, June 2024
[4]
Attia sees NMN as effective for replenishing NAD⁺, but warns that evidence for actual lifespan extension in humans is still limited.
Prof. Andrea Maier – Clinical evidence from Singapore
Background: Professor of 'Healthy Longevity' at the National University of Singapore and the Vrije Universiteit Amsterdam, physician and researcher in geriatrics and aging.“600 mg NMN per day increases NAD⁺ levels and physical performance, without side effects.” — PubMed RCT LIn Yi et al. (2023)[5]Maier was one of the few clinical researchers to test NMN in humans. Her results confirm: 600 mg of NMN per day is safe and effective in healthy men.
Dr. Bryan Johnson – Biohacker known for “Don't die”
Background: Tech entrepreneur and founder of the Blueprint Protocol, known for its extreme approach to rejuvenation and biomarker optimization.
“They basically work to get my intracellular NAD to level age 16 equivalent.” — Blueprint Notes via NAD.com (2023) [6]
Johnson combines NMN (500–1,000 mg) with NR and reports via biomarker measurements that his NAD⁺ levels are comparable to those of a 16-year-old.
Dr. Kris Verburgh – Visionary with scientific support
Background: Belgian physician and biogerontologist, author of The Food Hourglass and co-founder of the supplement brand NOVOS.“NMN has shown to counteract various aging processes in egg cells … improve stem cell function … and enhance muscular health in elderly men.” — krisverburgh.com, Best Anti-aging Supplements[7]As co-founder of NOVOS, Verburgh is positive about NMN, provided it is used within a broader longevity strategy with nutrition, exercise and other targeted interventions.
Dr. Mark Hyman – Functional medicine in practice
Background: Doctor specialized in functional medicine, author of, among others: Young Forever, known for podcast appearances at Huberman Lab and The Doctor's Farmacy, among others.“I take 1000 mg of NMN daily — it's not a cure-all, but a great optimization tool.” — Huberman Lab Podcast, guest appearance[8]Dr. Hyman sees NMN as a smart addition to his stack for aging and energy, but remains realistic: not a panacea, but a valuable tool for optimization.
Important notes and legislative status
NMN is found safe in several human studies (including by Andrea Maier)
Yet long-term safety remains not fully established
In the USA (FDA) and Australia NMN is now classified as a drug. Although the FDA legally states that NMN is no longer a supplement, it is expected that it will not actively enforced for the time being as long as: it does not identify any acute safety risks
In Europe, NMN may not be sold as a supplement, but only as a research chemical for research purposes. According to the EU β-NMN (Nicotinamide mononucleotide) officially classified as one since 2022 Novel Food. “Novel foods” are ingredients that were not significantly consumed in Europe before May 15, 1997 and therefore require separate approval
If you prefer a NAD supplement that has been approved, go for NR instead of NMN. Also read our article about the differences between NR & NMN
Quality of NMN products varies widely – choose reliable suppliers
Conclusion
NMN is promising, especially for energy, recovery and aging
Note: choose pure NMN with tested dosage and origin
Combine NMN smartly with lifestyle: fasting, exercise, antioxidants
- If under the care of a doctor, consult first before using supplements.
Resources & Quotes from Longevity Experts about NMN
🧬 Dr. David Sinclair
NMN increases my NAD⁺ levels and activates sirtuins. I take 1 gram daily.
— Dr. David Sinclair
Context: Harvard geneticist, author of Lifespan. Uses NMN, resveratrol and metformin as a longevity stack.
🧬 Dr. Andrew Huberman
NMN can increase NAD⁺ and optimize energy… but human evidence is still limited.
— Dr. Andrew Huberman
Context: Stanford neurobiologist. Uses sublingual NMN and discusses NAD⁺ in relation to energy and cognition.
🧬 Dr. Rhonda Patrick
NMN and NR seem to do remarkable thIn gs to rodents.
— Dr. Rhonda Patrick
Context: Biomedical researcher. Enthusiastic about preclinical NMN research, cautious about human use.
🧬 Dr. Peter Attia
TakIn g oral NAD⁺ precursors like NMN and NR is the most effective method for replenishIn g NAD⁺ levels.
— Dr. Peter Attia
Context: Longevity doctor, known for The Drive podcast. Sees NMN as effective, but wants more clinical evidence.
🧬 Prof. Andrea Maier
600 mg NMN per day increases NAD⁺ levels and physical performance, without side effects.
— Prof. Andrea Maier
Context: Geriatrician and aging researcher at NUS and VU. First clinical trial of NMN in humans.
🧬 Dr. Bryan Johnson
They basically work to get my In tracellular NAD to level age 16 equivalent.
— Dr. Bryan Johnson
Context: Biohacker and founder of Blueprint. Takes 500–1000 mg NMN and NR with biomarker monitoring.
🧬 Dr. Kris Verburgh
NMN has shown to counteract various agIn g processes In egg cells … improve stem cell function … and enhance muscular health In elderly men.
— Dr. Kris Verburgh
Context: Belgian doctor and biogerontologist. Co-founder of NOVOS and supporter of NMN in a broader strategy.
🧬 Dr. Mark Hyman
I take 1000 mg of NMN daily — it's not a cure-all, but a great optimization tool.
— Dr. Mark Hyman
Context: Functional medicine doctor. Known for Young Forever and The Doctor's Farmacy.
Frequently asked questions about NMN and science
What exactly is NAD⁺?
NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme involved in energy production, DNA repair and activation of sirtuins — essential for cell renewal and healthy aging.
Why not just take NAD⁺ yourself?
NAD⁺ is too large to be properly absorbed. It is largely broken down in the intestines. Precursor substances such as NMN or NR are better absorbed and converted into NAD⁺.
Is NMN better than NR?
NMN needs to go through fewer steps to become NAD⁺. Some studies indicate faster absorption and better efficacy, especially with sublingual or liposomal administration.
But some people still choose NR?
Beats. NR is cheaper, stable and well researched. It works well for many people, especially in combination with a healthy lifestyle.
Does NMN also work in young healthy people?
Yes, although the effects are more subtle. In the elderly or those with low NAD⁺ levels, the results are often more noticeable, such as increased energy or sharpness.
Why is TMG often combined with NMN?
TMG supports methylation. NMN increases NAD⁺ but can also consume methyl groups. TMG helps to maintain that balance.
Should you use NMN cyclically or daily?
Most people use it every day. Cyclic use is not mandatory, but some feel better with 5 days on, 2 days of rest.
What is the best way to take NMN?
Under the tongue (sublingual) provides the fastest absorption. Liposomal powder in yogurt or combined with resveratrol also works well.
How does NMN actually end up in the cell?
Via specific transport proteins (such as Slc12a8) or by first being converted into NR/NAM and then forming NAD⁺ in the cell.
Are there human studies being done with NMN?
Yes, for example by Prof. Andrea Maier. In her 2023 study, 600 mg of NMN per day was found to be safe with positive effects on physical performance.
Are there any known side effects of NMN?
Hardly. Some users report mild headaches, insomnia, or stomach upset at high doses. Start low and build up.
Is NMN also in food?
Yes, in small amounts in broccoli, cucumber and avocado. But you have to eat pounds for an effective dose.
Does NMN really help prevent aging?
It increases NAD⁺, which is crucial for cell health and repair. But it's not a magic bullet. It works best in combination with lifestyle interventions.
When is NMN not recommended?
Consultation with a doctor is necessary during pregnancy, breastfeeding or use of medication (such as chemo or immune inhibitors).